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Sequence & Structure

SNAP-8 Sequence, Molecular Weight & Chemical Identity

3 min readPublished 2025-01-10Quality Peptide USA Research

SNAP-8 (acetyl octapeptide-3) is a synthetic 8-amino-acid peptide developed as an extension of the SNAP-25 protein sequence involved in SNARE complex formation. It is used in topical research models focused on neurotransmitter exocytosis.. This guide covers sequence & structure for SNAP-8 — written for laboratory researchers sourcing US-synthesized peptides from Quality Peptide USA.

Primary Sequence

The primary sequence of SNAP-8 is recorded as: Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-OH. Sequence integrity is verified during release testing using analytical reverse-phase HPLC compared against a reference standard, with mass spectrometry confirming the expected molecular ion.

Molecular Formula and Weight

SNAP-8 carries the molecular formula C40H64N12O17S and a calculated monoisotopic weight of approximately ≈ 1025.07 g/mol. These values are essential for accurate molar-concentration calculations during reconstitution and for normalizing dose curves across studies.

Identifiers and Synonyms

CAS Registry: 868844-74-0. SNAP-8 is also referenced in the literature under its full chemical name and developmental designations. When searching publications, querying both the common and chemical names typically surfaces the broadest body of work.

Structural Notes for Researchers

SNAP-8 is supplied as a lyophilized solid with a white to off-white appearance. Researchers should reconstitute in sterile bacteriostatic water unless their assay calls for a specific buffer (e.g., 0.1% acetic acid for hydrophobic peptides). Quality Peptide USA publishes the full chemical-identity card on every product page so that incoming-QC checks can be performed against a known reference.

Research Use Only

All content is for laboratory and in-vitro research contexts only. Not intended to diagnose, treat, or prevent any condition. Not for human or veterinary consumption.

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